Myo-Liga-Ten

Peptide Hydrolase/Proteolytic Enzyme Formulations

"ORAL PROTEOLYTIC ENZYMES IN THE TREATMENT OF ATHLETIC INJURIES: A DOUBLE BLIND STUDY" by Richard E. Deitrick, M.D. in the October 1965 issue of "THE PENNSYLVANIA MEDICAL JOURNAL," came to the conclusion, "Oral enzymes accelerate healing."  In view of the results of his research, he decided to add oral enzymes as a routine to his treatment of athletic injuries.  Benefit of the proteolytic enzyme preparation tested was not limited to one type of athletic injury, but was obtained in a variety of injuries normally encountered in contact sports.

In a 1970 study published in the September 1970 edition of "THE BRITISH JOURNAL OF CLINICAL PRACTICE," a preparation containing trypsin and chymotrypsin was tested on  professional footballers.  Neither the physician or patients knew if they were being given the enzyme preparation or a placebo until after the study. The authors concluded, "two separately conducted double blind trials in the treatment of minor injuries sustained by professional footballers has confirmed the value of proteolytic enzyme therapy in resolving inflammation and associated edema and increasing recovery rates.  The value is most marked in accelerating recovery from haematomata and swellings but some benefit can also be obtained in sprains."   They further stated, " The overall reduction in recovery time is 1.3 days for haematomata and 2.4 days for sprains.  These reductions correspond to an approximate 27% decrease in recovery time."  Both the placebo group and the enzyme group, received physical therapy treatments.

In "TRYPSIN IN THE TREATMENT OF SWELLINGS OF THE HEAD AND NECK" published in the December, 1958 issue of the "AMERICAN JOURNAL OF SURGERY," the authors conclude, "Our impression is that the trypsin is of benefit whether the swelling  and inflammation is due to infection or to trauma.   The impression is also gained that the swellings abated more rapidly when trypsin was used than when it was not, thus enhancing surgical repair."

"ORAL ANTI-INFLAMMATORY ENZYME THERAPY IN INJURIES IN PROFESSIONAL FOOTBALLERS," published in the April, 1967 issue of "THE PRACTITIONER" reported that "the results reported here confirmed our impressions" that the preparation tested "is effective in reducing the time lost through soft-tissue injury in professional association football.  Doubtless these conclusions are equally valid for similar types of traumatic injury sustained in other circumstances - sporting, industrial or accidental." "No side effects were observed."

In "ORAL ENZYME TABLETS IN THE TREATMENT OF BOXING INJURIES," published in the April, 1967 edition of "THE PRACTITIONER," the author concludes that an enzyme preparation of trypsin and chymotrypsin appears "to be useful both prophylactically and for the treatment of boxing injuries.  These results suggest that they might also be used generally for traumatic soft-tissue injuries." Among 55 injured boxers who received oral enzyme tablets, bruising, abrasions, haematomas and sprains cleared up in four to five days, and boxing was resumed in one week.  Four cuts in the upper lip did not require suturing and cleared up in a week.  Four sutured cuts in the orbital region healed completely in two weeks.   Among 34 injured boxers who received dummy tablets (placebos), bruising, abrasions, haematomas and sprains took two to three weeks to clear.  Four sutured cuts took four weeks to heal completely.  450 boxers participated in the investigation.  225 received enzyme tablets prophylactically half-an-hour to one hour before boxing.   The remaining 225 received dummy tablets (placebos) half-an-hour to one hour before boxing.

In "TREATMENT OF SCIATICA DUE TO INTERVERTEBRAL DISC HERNIATION," published in 1971 in "RHEUMATOLOGY AND PHYSICAL MEDICINE" (VOL.XI, NO.1) the authors conclude that when symptoms of sciatica are due to the herniated intervertebral disc producing inflammatory edema in the nerve root, then proteolytic enzymes (trypsin and chymotrypsin) can be expected to exert a beneficial effect.  "Since orally administered enzymes have very few undesirable side-effects, this treatment is suitable for all patients presenting with sciatica due to intervertebral disc herniation.  The clinical benefit obtained is presumably due to decrease of inflammatory edema in the nerve root, and in suitable cases clinical results have been spectacularly good . . . Numerous experimental and clinical workers have demonstrated the effect of proteolytic enzymes in resolving inflammatory edema, and it is exactly this effect that we have utilized in the treatment of sciatica."

"RESOLUTION OF POSTOPERATIVE SWELLING FOLLOWING ORAL SURGERY" published in "ORAL SURGERY" in 1967 concluded that oral proteolytic enzyme as an aid in the relief of swelling and pain following oral surgical procedures evaluated by a double-blind technique in209 patients "inhibits the development of postoperative edema and swelling."  The proteolytic enzymes did not appear to inhibit the development of swelling during the first 24 hours postoperatively. However, there was a 50% increase in the number of patients with moderate or severe swelling during the next 24 hours in the placebo treated patients, whereas no significant increase occurred among those who received the proteolytic enzymes.

In "INHIBITION OF THE RESPONSE TO THERMAL INJURY BY ORAL PROTEOLYTIC ENZYME," the authors conclude that inflammation resulting from the experimental burn technique he used was significantly less in the enzyme treated cases (versus placebo) and that the difference became greater with the elapsed time during the test period. "THE JOURNAL OF CLINICAL PHARMACOLOGY," August-September (1972)

"GASTROINTESTINAL ABSORPTION AND ANTI-INFLAMMATORY EFFECT OF BROMELAIN" (JAPAN JOURNAL OF PHARMACOLOGY, 1972) reported, "The data obtained here indicate that orally administered Bromelain is absorbable from the gastrointestinal tract and exhibits fairly potent anti-inflammatory activity on the exudative phases provided it is in the from of enteric-coated capsules."  When discussing the inhibitory effect of Bromelain on edema, the paper says, "This inhibitory effect was highly significant and almost equivalent to that obtained with hydro-cortisone."

"TREATMENT OF INFLAMMATION AND EDEMA WITH BROMELAIN" (DELAWARE MEDICAL JOURNAL, 1962) reported after treating more than 200 patients with Bromelain for soft tissue injuries, distortions, fractures, cutaneous infections caused by staphylococci, anal and perianal inflammations and infected wounds after surgery, that it was felt the medication had a good effect in 74% of the cases.

"THE USE OF BROMELAIN IN SINUSITIS" (EYE, EAR, NOSE, THROAT MONTHLY, 1966) reported a good effect of Bromelain given orally to 60 persons with inflammation in the nose and its cavities.  The author found diminished secretion and reduced edema in the nasal mucosa.

"THE ACCELERATION OF WOUND HEALING WITH CARTILAGE," (SURGERY, GYNECOLOGY & OBSTETRICS, SEPT. 1957) reports "the effect of cartilage upon the tensile strength of wounds which has been demonstrated in these experiments is unique.  No other substance has been shown to produce such and increase under normal nutritional and endocrine circumstances."

In "ACCELERATION OF HEALING WITH ZINC SULFATE," which appeared in the March, 1967 "ANNALS OF SURGERY," the authors conclude, "Zinc is intimately involved in healing. Zinc deficient animals heal poorly.   Zinc also appears to play an important role in human healing.  Patients with severe burns develop significant zinc deficits and it is likely that patients with other healing problems also have zinc stores inadequate to meet the demands of healing tissues.   Oral medication with 220mg of zinc sulfate USP three times a day, resulted in the acceleration  of healing by 43% in a well controlled study of young men with granulating wounds.  Zinc therapy deserves a trial as an adjunct in the treatment of patients with healing problems."

In "THE EFFECTS OF ZINC ON FATIGUE OF STRIATED MUSCLE,"   which appeared in "JOURNAL OF SPORTS MEDICINE," (June, 1979), the authors conclude "this experiment indicates that zinc given daily to rats did decrease fatigue in striated muscle significantly.  This study suggests that zinc given orally causes increased stamina as a result of its effect of prolonging muscle contraction."

"ZINC AND MUSCLE STRENGTH AND ENDURANCE," published in the November 1982 issue of "ACTA PHYSIOLOGICAL SCANDINAVICA," reports "After zinc intake, a significant increase in isometric endurance was observed after 14 days of zinc treatment.  The observed increase of muscle strength and endurance after zinc treatment is consistent with findings in rats (Richardson & Drake, 1979). Its signifcance is difficult to assess but it may have direct application in athletes who demonstrate reduced blood zinc levels (Haralambre, 1981). Whatever the mechanism behind the effect of zinc, zinc supplementation may be of practical importance not only for sportsmen, but also in many clinical situations where malabsorption or lower intake may induce zinc depletion and thereby influence muscle strength and fatigue.  Subjects exposed to loss of zinc by sweating  (Haralambre, 1981, Thorstensson & Karisson, 1976) serve as an example of a group possibly suitable for administration of zinc to improve muscle performance."

SIDE EFFECTS OF CORTICOSTEROIDS SUCH AS TRIAMCINOLONE, BETAMETHASONE, HYDROCORTISONE, CORISONE ACETATE, DEXAMETHASONE, PREDNISONE, METHYLPREDNISOLONE, PREDNISOLONE ACETATE

VS.

ZYTRON'S PEPTITE HYDROLASE/PROTEOLYTIC ENZYME FORMULATION

This medication may cause:                                            Corticosteroids                     Zytron's Formula

Muslce Weaknes                                                                 Yes                                         No

Loss of Muscle Mass                                                           Yes                                         No

Pathological Fractures                                                          Yes                                         No

Tendon Rupture                                                                   Yes                                         No

Impaired Wound Healing                                                     Yes                                         No

Lowers Resistance to Infection                                             Yes                                        No

Septic Arthritis                                                                     Yes                                        No

Increased Sweating                                                              Yes                                        No

Congestive Heart Failure                                                      Yes                                        No

Hypertension                                                                        Yes                                       No

Osteoporosis                                                                        Yes                                       No

Aseptic Necrosis                                                                  Yes                                       No

Perforation of small and large bowel                                      Yes                                       No

Convulsions                                                                          Yes                                       No

Vertigo                                                                                 Yes                                       No

Headache                                                                             Yes                                       No

Suppression of Growth                                                         Yes                                       No

Malaise                                                                                 Yes                                      No

Cataracts                                                                               Yes                                     No

Other fluid and electrolyte disturbances                                  Yes                                      No

Bleeding problems                                                                 Yes                                      No

Lowers resistance to Systemic Fungus Infections                    Yes                                      No

Study after study has shown the ingredients

in this preparation to be very safe                                             No                                    Yes